5,498 research outputs found
Air quality at risk: Brexit and lobbying from member states could stall progress on reducing pollution
Air pollution is linked to thousands of premature deaths across Europe each year and the European Union has a key role in addressing the problem. Roy M. Harrison states that although much progress has been made in improving air quality, lobbying from member states has led to a notable weakening of the resolve of the Commission to propose a real tightening of emissions ceilings. It also remains to be seen how Brexit will affect Britain’s air quality given the EU has been a major driver of action in the UK
Evaluation of the cancer risk from PAHs by inhalation:Are current methods fit for purpose?
There is ample evidence from occupational studies that exposure to a mixture of Polycyclic Aromatic Hydrocarbons
(PAHs) is causally associated with an increased incidence of lung cancers. In both occupational atmospheres
and ambient air, PAHs are present as a mixture of many compounds, but the composition of the mixture
in ambient air differs from that in the occupational atmosphere, and varies in time and space in ambient air.
Estimates of cancer risk for PAH mixtures are based upon unit risks which derive from extrapolation of occupational
exposure data or animal model data, and in the case of the WHO use one compound, benzo[a]pyrene as
a marker for the entire mixture, irrespective of composition. The U.S. EPA has used an animal exposure study to
derive a unit risk for inhalation exposure to benzo[a]pyrene alone, and there have been a number of rankings of
relative carcinogenic potency for other PAHs which many studies have used to calculate a cancer risk from the
PAHs mixture, frequently incorrectly by adding the estimated relative risks of individual compounds, and
applying the total “B[a]P equivalent” to the WHO unit risk, which already applies to the entire mixture. Such
studies are often based upon data solely for the historic US EPA group of 16 compounds which do not include
many of the apparently more potent carcinogens. There are no data for human cancer risk of individual PAHs,
and conflicting evidence of additivity of PAH carcinogenicity in mixtures. This paper finds large divergences
between risk estimates deriving from the WHO and U.S. EPA methods, as well as considerable sensitivity to the
mixture composition, and assumed PAH relative potencies. Of the two methods, the WHO approach appears
more likely to provide reliable risk estimates, but recently proposed mixture-based approaches using in vitro
toxicity data may offer some advantages.peer-reviewe
Like Sign Dilepton Signature for Gluino Production at LHC with or without R Conservation
The isolated like sign dilepton signature for gluino production is
investigated at the LHC energy for the conserving as well as the and
violating SUSY models over a wide range of the parameter space. One gets
viable signals for gluino masses of 300 and 600 GeV for both conserving and
violating models, while it is less promising for the violating case.
For a 1000 GeV gluino, the violating signal should still be viable; but the
conserving signal becomes too small at least for the low luminosity option
of LHC.Comment: (e-mail: [email protected]) Latex: No. of pages 21, no. of figures
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